LymphedemaV1, Main, Exploration, bibRecord, 002978

Interleukin-10- and Transforming Growth Factor β-Independent Regulation of CD8+ T Cells Expressing Type 1 and Type 2 Cytokines in Human Lymphatic Filariasis

Identifieur interne : 002978 ( Main/Exploration ); précédent : 002977; suivant : 002979

Interleukin-10- and Transforming Growth Factor β-Independent Regulation of CD8+ T Cells Expressing Type 1 and Type 2 Cytokines in Human Lymphatic Filariasis

Auteurs : Rajamanickam Anuradha [Inde] ; Parakkal Jovvian George [Inde] ; Paul Kumaran [Inde] ; Thomas B. Nutman [États-Unis] ; Subash Babu [Inde, États-Unis]

Source :

Clinical and Vaccine Immunology : CVI [ 1556-6811 ] ; 2014.

RBID : PMC:4248783

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Cytokines (métabolisme), Facteur de croissance transformant bêta (physiologie), Filariose lymphatique (immunologie), Humains, Interleukine-10 (physiologie), Lymphocytes T CD4+ (immunologie), Lymphocytes T CD8+ (immunologie), Lymphocytes auxiliaires Th1 (immunologie), Lymphocytes auxiliaires Th2 (immunologie), Sujet âgé.
MESH :
- immunologie : Filariose lymphatique, Lymphocytes T CD4+, Lymphocytes T CD8+, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2.
- métabolisme : Cytokines.
- physiologie : Facteur de croissance transformant bêta, Interleukine-10.
- Adulte, Adulte d'âge moyen, Humains, Sujet âgé.

English descriptors

KwdEn :
- Adult, Aged, CD4-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (immunology), Cytokines (metabolism), Elephantiasis, Filarial (immunology), Humans, Interleukin-10 (physiology), Middle Aged, Th1 Cells (immunology), Th2 Cells (immunology), Transforming Growth Factor beta (physiology).
MESH :
- chemical , metabolism : Cytokines.
- immunology : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Elephantiasis, Filarial, Th1 Cells, Th2 Cells.
- chemical , physiology : Interleukin-10, Transforming Growth Factor beta.
- Adult, Aged, Humans, Middle Aged.

Abstract

Lymphatic filariasis is known to be associated with diminished CD4⁺ Th1 and elevated CD4⁺ Th2 responses to parasite-specific antigens. The roles of cytokine-expressing CD8⁺ T cells in immune responses to filarial infections are not well defined. To study the roles of CD8⁺ T cells expressing type 1, type 2, and type 17 cytokines in filarial infections, we examined the frequencies of these cells in clinically asymptomatic, patently infected (INF) individuals, directly ex vivo and in response to parasite or nonparasite antigens; these frequencies were compared with the results for individuals with filarial lymphedema (i.e., clinical pathology [CP]) and those without active infection or pathology (i.e., endemic normal [EN]). INF individuals exhibited significant decreases in the frequencies of CD8⁺ T cells expressing tumor necrosis factor alpha (TNF-α), gamma interferon (IFN-γ), and interleukin-22 (IL-22) at baseline and/or in response to filarial antigens, compared with CP and EN individuals. In contrast, the same individuals exhibited significant increases in the frequencies of CD8⁺ T cells expressing IL-4, IL-5, IL-9, IL-13, and IL-21, compared with CP and/or EN individuals. Curative treatment resulted in significantly increased frequencies of CD8⁺ T cells expressing IL-2 and significantly decreased frequencies of CD8⁺ T cells expressing type 2 cytokines. Finally, the regulation of these responses appears to be independent of IL-10 and transforming growth factor β (TGF-β), since blockade of IL-10 or TGF-β signaling did not significantly alter the frequencies of type 1 or type 2 cytokine-expressing CD8⁺ T cells. Our findings suggest that alterations in the frequencies of cytokine-expressing CD8⁺ T cells are characteristic features of lymphatic filarial infections.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248783

DOI: 10.1128/CVI.00598-14
PubMed: 25253667
PubMed Central: 4248783

Affiliations:

Le document en format XML

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 T Cells Expressing Type 1 and Type 2 Cytokines in Human Lymphatic Filariasis</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Interleukin-10- and Transforming Growth Factor β-Independent Regulation of CD8<sup>+</sup>
 T Cells Expressing Type 1 and Type 2 Cytokines in Human Lymphatic Filariasis</title>
<author><name sortKey="Anuradha, Rajamanickam" sort="Anuradha, Rajamanickam" uniqKey="Anuradha R" first="Rajamanickam" last="Anuradha">Rajamanickam Anuradha</name>
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<term>CD4-Positive T-Lymphocytes (immunology)</term>
<term>CD8-Positive T-Lymphocytes (immunology)</term>
<term>Cytokines (metabolism)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Humans</term>
<term>Interleukin-10 (physiology)</term>
<term>Middle Aged</term>
<term>Th1 Cells (immunology)</term>
<term>Th2 Cells (immunology)</term>
<term>Transforming Growth Factor beta (physiology)</term>
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<term>Adulte d'âge moyen</term>
<term>Cytokines (métabolisme)</term>
<term>Facteur de croissance transformant bêta (physiologie)</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Humains</term>
<term>Interleukine-10 (physiologie)</term>
<term>Lymphocytes T CD4+ (immunologie)</term>
<term>Lymphocytes T CD8+ (immunologie)</term>
<term>Lymphocytes auxiliaires Th1 (immunologie)</term>
<term>Lymphocytes auxiliaires Th2 (immunologie)</term>
<term>Sujet âgé</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term>
<term>Lymphocytes T CD4+</term>
<term>Lymphocytes T CD8+</term>
<term>Lymphocytes auxiliaires Th1</term>
<term>Lymphocytes auxiliaires Th2</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>CD8-Positive T-Lymphocytes</term>
<term>Elephantiasis, Filarial</term>
<term>Th1 Cells</term>
<term>Th2 Cells</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Facteur de croissance transformant bêta</term>
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<term>Transforming Growth Factor beta</term>
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<term>Aged</term>
<term>Humans</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en"><p>Lymphatic filariasis is known to be associated with diminished CD4<sup>+</sup>
 Th1 and elevated CD4<sup>+</sup>
 Th2 responses to parasite-specific antigens. The roles of cytokine-expressing CD8<sup>+</sup>
 T cells in immune responses to filarial infections are not well defined. To study the roles of CD8<sup>+</sup>
 T cells expressing type 1, type 2, and type 17 cytokines in filarial infections, we examined the frequencies of these cells in clinically asymptomatic, patently infected (INF) individuals, directly <italic>ex vivo</italic>
 and in response to parasite or nonparasite antigens; these frequencies were compared with the results for individuals with filarial lymphedema (i.e., clinical pathology [CP]) and those without active infection or pathology (i.e., endemic normal [EN]). INF individuals exhibited significant decreases in the frequencies of CD8<sup>+</sup>
 T cells expressing tumor necrosis factor alpha (TNF-α), gamma interferon (IFN-γ), and interleukin-22 (IL-22) at baseline and/or in response to filarial antigens, compared with CP and EN individuals. In contrast, the same individuals exhibited significant increases in the frequencies of CD8<sup>+</sup>
 T cells expressing IL-4, IL-5, IL-9, IL-13, and IL-21, compared with CP and/or EN individuals. Curative treatment resulted in significantly increased frequencies of CD8<sup>+</sup>
 T cells expressing IL-2 and significantly decreased frequencies of CD8<sup>+</sup>
 T cells expressing type 2 cytokines. Finally, the regulation of these responses appears to be independent of IL-10 and transforming growth factor β (TGF-β), since blockade of IL-10 or TGF-β signaling did not significantly alter the frequencies of type 1 or type 2 cytokine-expressing CD8<sup>+</sup>
 T cells. Our findings suggest that alterations in the frequencies of cytokine-expressing CD8<sup>+</sup>
 T cells are characteristic features of lymphatic filarial infections.</p>
</div>
</front>
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Serveur d'exploration sur le lymphœdème

Interleukin-10- and Transforming Growth Factor β-Independent Regulation of CD8+ T Cells Expressing Type 1 and Type 2 Cytokines in Human Lymphatic Filariasis

Interleukin-10- and Transforming Growth Factor β-Independent Regulation of CD8+ T Cells Expressing Type 1 and Type 2 Cytokines in Human Lymphatic Filariasis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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